The Novter Trojan, also known as Nodersok or Divergent, is the latest Trojan to actively target Microsoft’s Windows Defender by attempting to disable it. This is becoming more common as we have seen TrickBot and Gootkit disable Windows Defender in recent variants. This will allow Trojans to download further malware without risk of Defender detecting them or for future definition updates from detecting existing malware. The good news is that the Windows 10 Tamper Protection feature would protect users from these types of attacks.
Source: https://www.bleepingcomputer.com/news/security/novter-trojan-sets-its-sights-on-microsoft-windows-defender/