Microsoft’s recent out-of-band KB5004945 PrintNightmare security updates are preventing Windows users from printing to certain Zebra printers. Microsoft has investigated this issue and plans to release an update addressing the issue within the next 1 2 business days. Zebra says it is only affecting printers directly attached to Windows devices via USB, not connected to a print server. Users can uninstall the update or uninstall the affected printer driver and reinstall using Administrative credentials. After uninstalling the update, users state that the printers work fine again.
Source: https://www.bleepingcomputer.com/news/microsoft/windows-security-update-kb5004945-breaks-printing-on-zebra-printers/