Windows 10 users have been reporting errors that programs are missing when they attempt to launch them. The issue is caused by incorrect debuggers or filters created for these programs under the Image File Execution Options registry key. This technique is commonly used to replace Windows system programs with third-party alternatives. Avast has recently pushed out an update that has caused incorrect IFEO entries to be created through the use of a filter pointing to C:Program Files (x86) Avast Cleanupautoreactivator.exe.
Source: https://www.bleepingcomputer.com/news/microsoft/recent-windows-10-updates-block-programs-from-running/