Microsoft released a new future called Tamper protection in Microsoft Defender ATP to provide next-gen security to their users and block the advanced and never before seen malware within a seconds. This feature builds on our previously announced Windows Defender Antivirus sandboxing capability and expands existing tamper protection strategies across Microsoft Defender Advanced Threat Protection. Microsoft enabled this future in both home and enterprise users, in this case, Enterprise users directly manage in this future via Microsofts Intune management portal. The local device admin users will not be able to change the setting due to the security concern to prevent locally override the setting by malicious apps.”]
Source: https://gbhackers.com/microsoft-s-new-tamper-protection/