Verizon researchers are offering some of the best advice I ve seen regarding the ongoing attacks against an unpatched Adobe Acrobat/PDF vulnerability. Dave Kennedy and Kevin Long from Verizon s security team are offering suggestions to reduce your exposure to these attacks. They include disabling JavaScript, disabling automatic rendering of PDFs in the browser to allow the user time to decide whether to launch a file or not. Anti-virus vendors are updating to detect malicious PDF using the new vulnerability. Some AV were preventing exploitation of this vulnerability since last summer.
Source: https://threatpost.com/how-mitigate-adobe-pdf-malware-attacks-030609/72428/