Microsoft Office programs support Macros written in Visual Basic for Applications (VBA), but they can also be used for malicious activities like installing malware. Dridex Malware and Locky Ransomware had made use of the malicious Macros to hijack systems. Microsoft recently unveiled a novel security feature to limit the Macro execution attack in MS Office 2016. The only way to run that particular Office file is to save it to a trusted location, allowing macros to run. If your organization relies on Macros, you can move files that use Macros into the company’s DMZ (Demilitarized Zone), also called Trusted Location.
Source: https://thehackernews.com/2016/03/macro-malware-protection.html